1. What is the main enzyme targeted by the IACS scientists in their cancer treatment research?
1. PARP1
2. TDP1
3. CDK2
4. ATP1
2. Where was this cancer treatment research conducted?
1. Indian Institute of Science
2. Indian Medical Association
3. Indian Association for the Cultivation of Science (IACS)
4. Indian Cancer Research Centre
3. Which drugs are mentioned as current cancer treatments that block Topoisomerase 1?
1. Camptothecin and Irinotecan
2. Paracetamol and Aspirin
3. Metformin and Insulin
4. Penicillin and Amoxicillin
4. What is the primary function of TDP1 in cancer cells?
1. Cell division
2. Protein synthesis
3. DNA repair
4. Energy production
5. Which protein is crucial for controlling the cell cycle?
1. CDK1
2. TDP1
3. Top1
4. ATP
6. What process makes TDP1 better at fixing DNA damage?
1. Methylation
2. Phosphorylation
3. Oxidation
4. Reduction
7. Which protein is responsible for adding a phosphate group to TDP1?
1. Top1
2. TDP2
3. CDK1
4. DNA
8. What is Topoisomerase 1’s role in cancer cells?
1. Cell death
2. Protein production
3. DNA replication
4. Energy metabolism
9. Why do some cancer treatments become less effective over time?
1. Patients develop allergies
2. Cancer cells become resistant
3. Drugs expire
4. Treatment costs increase
10. The proposed new therapy works by:
1. Increasing CDK1 production
2. Stimulating TDP1
3. Blocking CDK1 to prevent DNA repair
4. Enhancing DNA damage
11. In which organisms is TDP1 found?
1. Only in humans
2. Only in bacteria
3. Humans, yeast, and bacteria
4. Only in cancer cells
12. What type of medicine could this discovery lead to?
1. Preventive medicine
2. Precision medicine
3. Alternative medicine
4. General medicine
13. What makes this discovery significant for cancer treatment?
1. It’s cheaper than current treatments
2. It has no side effects
3. It could help treat resistant cancers
4. It prevents cancer formation
14. What is the next step in this research?
1. Human trials
2. Animal studies
3. Drug manufacturing
4. Market release
15. Which combination therapy is suggested by the research?
1. TDP1 and Top1 inhibitors
2. CDK1 and Top1 inhibitors
3. CDK1 and TDP1 enhancers
4. Top1 and DNA inhibitors
16. What happens when cancer cells become resistant to current treatments?
1. They grow faster
2. They spread more quickly
3. The treatments become less effective
4. They become smaller
17. What is the main goal of targeting TDP1?
1. To increase cell division
2. To prevent DNA repair in cancer cells
3. To boost immune response
4. To reduce inflammation
18. Where was this research conducted?
1. Mumbai
2. Delhi
3. Kolkata
4. Chennai
19. What type of damage does TDP1 repair?
1. Protein damage
2. Cell membrane damage
3. DNA breaks
4. Mitochondrial damage
20. How does CDK1 affect TDP1?
1. It destroys it
2. It blocks it
3. It enhances its function
4. It has no effect
21. What is the primary weakness being targeted in cancer cells?
1. Energy production
2. DNA repair mechanisms
3. Cell division
4. Protein synthesis
22. Why is understanding TDP1 important?
1. To prevent cancer
2. To improve cancer treatments
3. To diagnose cancer
4. To predict cancer risk
23. What makes cancer cells survive current treatments?
1. Increased cell division
2. DNA repair by TDP1
3. Protein production
4. Energy efficiency
24. What kind of inhibitors are currently used in cancer treatment?
1. CDK1 inhibitors
2. TDP1 inhibitors
3. Top1 inhibitors
4. DNA inhibitors
25. What process does the new treatment interfere with?
1. Cell division
2. Protein synthesis
3. DNA repair
4. Energy production